Environmental Chemistry Committee of the Long Island Subsection
High School Awards presented by the Long Island Subsection
2010 Officers
Chair:
Jordan Verdis
Department of Chemistry
Queensborough Community College
222-05 56th Ave
Bayside, NY 11364
718-631-6939
Email
Chair-Elect:
Clive Wynter
Department of Chemistry
Nassau Community College
One Education Drive
Garden City, NY 11530
516-572-7583
Email
Chair-Past:
Jun Shin
Department of Chemistry
Queensborough Community College
222-05 56th Ave
Bayside, NY 11364
718-631-6255
Email
Secretary:
Joe Landesberg
Department of Chemistry
Adelphi University
1 South Ave.
Garden City, NY 11530
516-877-4148
Email
Treasurer:
Phil Mark
Department of Chemistry
Nassau Comm College
One Education Drive
Garden City, NY 11530
Email
Directors-at-Large:
Eugene Brown
Department of Chemistry
Nassau Community College
One Education Drive
Garden City, NY 11530
Email
Ralph Stephani
St. John's University
Department of Chemistry
8000 Utopia Parkway
Jamaica, NY 11439-0001
718-990-5215
Email
Paris Svoronos
Department of Chemistry
Queensborough Community College
222-05 56th Ave
Bayside, NY 11364
718-631-6280
Email
Luis Vargas
Department of Chemistry
Queensborough Community College
222-05 56th Ave
Bayside, NY 11364
718-631-6939
Email
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LONG ISLAND CHEMICAL SOCIETY
Meetings
Our monthly seminars cover a broad range of topics and are open to all.
Students are encouraged to attend.
Hofstra University
Breslin Hall Room 211
(Please note that this is a different room than past seminars at Hofstra)
Directions
Seminar: 6:00 PM
Dinner: 7:30PM at a nearby restaurant ($25)
Spring 2010 Events
February 11, 2010
Dr. Sanjay Kumar
, Queens College
Towards Acquisition of Activity-Based Biosensors and Small Molecule Inhibitors of Nek2 - A Kinase Implicated In Cancer
A direct activity-based measurement of a kinase in a natural intracellular environment is crucial for correlating activity with its in-vivo function.
To date, majority of the traditional biochemical methods used to monitor intracellular kinase activity employ indirect approaches.
This process typically involves cell lysis and affinity purification of target kinase at a predetermined time interval, followed by kinase activity
measurements using radioactivity (e.g. 32P and 33P). Such indirect and discontinuous measurement of kinase activity is often not sufficient
for making intracellular functional assignments, because it is known that a complex cellular microenvironment can have a dramatic impact on kinase activity.
Nek2 is a centrosomal serine/threonine kinase and its expression is significantly elevated in many different forms of cancer.
Despite its involvement in a variety of cancer types, many of its precise intracellular roles in oncogenic transformation remain to be discovered
(e.g. how over-expression of Nek2 leads to tumor formation and progression, and, if over-expression is indeed correlated with aberrant activity of Nek2,
leading to uncontrolled cell proliferation). This gap in our understanding of Nek2 biology is primarily due to the lack of available chemical tools
needed for in-vivo applications. Furthermore, it needs to be established if small molecule inhibition of intracellular Nek2 kinase activity
is a promising strategy for cancer drug development. Currently there are no potent and specific inhibitory agents of Nek2 kinase. We are developing
activity-based, fluorescence-responsive specific biosensors, and small molecule inhibitory agents of Nek2 kinase that will be used to delineate the
undocumented function of this kinase in both normal and diseased cancer cells.
March 11, 2010
Dr. Vijaya Koripara
, St. John's University
Synthesis and Evaluation of OSI-930 Analogues for Tyrosine Kinase Inhibition and Reversal of ABCG2-Mediated Multidrug Resistance
c-Kit, a type III receptor tyrosine kinase (RTK), is widely over-expressed in seminoma, acute myeloid leukemia and in gastrointestinal stromal tumor.
KDR, a type V RTK is a key regulator of tumor angiogenesis. A dual inhibitor of these two kinases has been proposed to be an effective approach to treatment of cancer.
The quinoline domain of OSI-930 was modified with heteroatom substituted pyridyl and phenyl ring systems to evaluate the effect of these changes on their activity
in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and KDR. Results of the kinase inhibition assay along with the role
of OSI-930 analogues in the reversal of ABCG2-mediated multidrug resistance will be presented.
April 8, 2010
Dr. Melissa Van Alstine
, Adelphi University
Design of Fluorometric High-Throughput Screening Assays for Cytochrome P450s
April 23, 2010
10th Annual LI-ACS Chemistry Challenge
This is a chemistry knowledge competition between student teams from area two- and four-year institutions.
Thirty multiple choice questions (approximately 75% General and 25% Organic Chemistry) are asked in a friendly and exciting atmosphere
that brings colleges and their students and faculty together. Each team is made of three members. All are welcome and prizes will be awarded!
May 20, 2010
13th Annual Frances S. Sterrett Environmental Chemistry Symposium
Sustaining the Green Revolution
The annual Frances S. Sterrett Symposium is dedicated to presenting the public with up-to-date,
factual scientific information on environmental topics.
Website
June 2010
Long Island ACS High School Awards
Awards will be presented to students receiving the highest mark in chemistry from Suffolk, Nassau and Queens high schools.
Website
See
The Indicator
for current meeting information
American Chemical Society
New York Section, Inc.
Department of Chemistry
St. John's University
8000 Utopia Parkway
Jamaica, NY 11439
Phone 516-883-7510
Fax 516-883-4003
E-Mail Inquiries to our Office Administrator
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